POPA ReconResearchers discovered that in the brain’s most common kainate receptor, activation can be triggered solely through the two GluK5 subunits…
Researchers discovered that in the brain’s most common kainate receptor, activation can be triggered solely through the two GluK5 subunits, producing long-lasting, non-desensitizing currents even without full receptor occupancy. Structural studies revealed an unexpected communication mechanism between GluK5 and GluK2 subunits and a unique GluK5–GluK5 interaction that likely explains the receptor’s unusually slow deactivation, providing new targets for future neurological therapeutics. https://www.nature.com/articles/s41467-026-72226-w
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