POPA ReconResearchers developed a computational tool that improves DNA origami design by selecting scaffold sequences that minimize unintended strand…
Researchers developed a computational tool that improves DNA origami design by selecting scaffold sequences that minimize unintended strand interactions, a major cause of assembly errors. Experiments showed that optimized sequences dramatically increased folding success and mechanical uniformity in both 2D and 3D nanostructures, paving the way for more reliable DNA-based drug delivery systems, biomolecule carriers, and nanoscale devices. https://www.nature.com/articles/s41467-026-73387-4
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