POPA ReconResearchers discovered that neurons use an indirect delivery route, called transcytosis, to send key proteins along their long axons…
Researchers discovered that neurons use an indirect delivery route, called transcytosis, to send key proteins along their long axons. Studying the TrkA receptor, they found it first travels to the cell surface, is pulled back inside, then transported in vesicles along axons by the motor protein KIF1A. This pathway, triggered by nerve growth factor, is crucial for maintaining synaptic transmission and may inform future treatments for nerve injury and neurodegenerative disease. https://www.science.org/doi/10.1126/scisignal.aea7078
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